Endometriosis Knowledgebase


A repository for genes associated with endometriosis

Results


PMID 20537326
Gene Name RAGE
Condition Endometriosis
Association Associated
Population size 48
Population details 48 (28 study patients, 20 controls)
Sex Female
Associated genes RAGE, EN-RAGE, COX-2
Other associated phenotypes Endometriosis
Implication of the RAGE-EN-RAGE axis in endometriosis.

Int J Gynaecol Obstet. 2010 Sep;110(3):199-202. doi: 10.1016/j.ijgo.2010.03.037.

Sharma, Indu| Dhawan, Veena| Saha, Subhash Chand| Rashmi, Bagga| Dhaliwal, Lakhbir Kaur

Department of Experimental Medicine & Biotechnology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

OBJECTIVE: To investigate the involvement of the receptor gene for advanced glycation (RAGE), its ligand EN-RAGE, and COX-2 in endometriosis. METHODS: The mRNA and protein expression of the corresponding genes were determined from endometriotic cells from 28 study patients and healthy endometrial stromal cells from 20 controls by semiquantitative RT-PCR and Western blot analysis, respectively, using beta-actin as an invariant control. RESULTS: The expression of COX-2, RAGE, and EN-RAGE was significantly increased, as evidenced by the significantly greater mRNA and protein expression in the cells of the study patients (P<0.001). Previous treatment for endometriosis did not lessen mRNA and protein expression (P<0.001). CONCLUSION: Our findings strengthen the hypothesis of an underlying inflammation in the pathophysiology of endometriosis and suggest exploring anti-inflammatory therapies as adjunct treatment.

Mesh Terms: Adult| Advanced Glycosylation End Product-Specific Receptor| Case-Control Studies| Cyclooxygenase 2/genetics/*metabolism| Endometriosis/*metabolism| Endometrium/cytology/*metabolism| Female| Gene Expression| Humans| Receptors, Immunologic/genetic